| Western Air Express (WAE) (LA to KC route) | 05/15/1929 | 07/15/1930 | Merged to become TWA |
| Transcontinental Air Transport (TAT) | 07/07/1929 | 07/15/1930 | Merged to become TWA |
| Transcontinental and Western Air (TWA) | 07/16/1930 | 12/31/1945 | Changed to Trans World Airline |
| Trans World Airlines (TWA) | 01/01/1946 | 12/01/2001 | Merged into American |
| Mid Continent Air Express (MCAE) | 09/21/1929 | 09/26/1931 | |
| Western Air Express (WAE) (CYS to ELP Route) | 09/27/1931 | 02/01/1934 ? | |
| Varney Speed Lines | 07/15/1934 | 06/30/1937 | Changed to Continental |
| Continental Airlines (Periods with no Mainline Flights) | 07/01/1937 | 03/31/2012 | Merged into United |
| Pioneer Air Lines | 05/01/1948 | 03/31/1955 | Merged into Continental |
| Monarch Air Lines | 04/01/1947 | 05/31/1950 | Merged into Frontier |
| Frontier Airlines | 06/01/1950 | 08/24/1986 | |
| Trans Texas Airways/Texas International | 10/15/1963 | 10/30/1982 | Merged into Continental |
| Bonanza | 07/01/1966 | 08/01/1966 | |
| American (Periods with no Mainline Flights 2020/2021) | 01/20/1979 | Current | |
| Eastern | 11/01/1979 | 08/31/1988 | |
| Southwest | 04/03/1980 | Current | |
| Western | 10/25/1981 | 3/31/1987 | Merged into Delta |
| United (Periods with no Mainline Flights) | 06/15/1982 | Current | |
| Delta (Periods with no Mainline Flights 2020/2021) | 02/15/1983 | Current | |
| Pacific Southwest (PSA) | 06/15/83 | 04/16/85 | Merged into USAir |
| America West | 12/01/1983 | 11/03/2007 | Merged into US Airways |
| Wien Air Alaska | 03/02/1984 | 05/31/1984 | |
| USAir | 04/09/1988 | 09/03/1997 | |
| Braniff | 05/01/1988 | 09/27/1989 | |
| PanAm | 12/15/1989 | 02/06/1990 | |
| Northwest | 10/01/1992 | 01/30/2010 | Merged into Delta |
| Aerolitoral/AeroMexico Connect | 11/01/1993 | 3/5/1994 | |
| Aerolitoral/AeroMexico Connect | 02/09/2009 | 01/06/2010 | |
| Frontier (Periods with No Mainline Flights 1994) | 10/13/1994 | 01/06/2014 | |
| Frontier (Periods with No Mainline Flights 1994) | 10/24/2017 | 01/01/2023 | |
| SkyWest (Periods with No Flights) | 05/01/1995 | Current | |
| Reno Air | 10/03/1995 | 03/31/1998 | |
| Mountain Air Express/Western Pacific | 06/29/1997 | 11/15/1997 | |
| Great Plains | 05/25/2001 | 01/23/2004 | |
| American Eagle/Envoy (Periods with No Flights) | 01/31/2002 | 02/14/2002 | |
| American Eagle/Envoy (Periods with No Flights) | 11/02/2008 | Current | |
| Mesa (Major Airline Code-Share Operations) | 07/15/2002 | Current | |
| ExpressJet (Major Airline Code-Share Operations) | 01/07/2003 | 08/02/2020 | |
| Republic Airways (Periods with No Flights) | 03/04/2007 | 03/03/2022 | |
| ExpressJet (Independent Operation) | 04/16/2007 | 08/30/2008 | |
| US Airways (Periods with No Mainline Flights) | 11/04/2007 | 10/16/2015 | Merged into American |
| JetBlue | 04/22/2013 | 06/14/2020 | |
| JetBlue | 10/01/2020 | 10/29/2022 | |
| JetBlue | 03/26/2023 | Current | |
| Alaska (No Mainline Flights 11/04/2018-12/15/2018) | 09/18/2014 | Current | |
| Allegiant (Periods with No Flights) | 06/02/2016 | 05/02/2022 | |
| Volaris | 11/17/2018 | 06/27/2019 | |
| CommuteAir (Periods with No Flights) | 12/17/2020 | Current | |
| Spirit | 08/03/2022 | Current | |
